Pathophysiology of Type 2 Diabetes Mellitus

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[Pathophysiology of type 2 diabetes mellitus].

The development of type 2 diabetes is usually associated with a combination of pancreatic β-cell dysfunction and insulin resistance in various insulin target tissues such as the liver, muscle and adipocytes. Normal β-cells can compensate for insulin resistance by increasing insulin secretion or β-cell mass, but insufficient compensation leads to the onset of glucose intolerance. Once hyperglyce...

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Both Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) are two common forms of disease worldwide and many studies indicate that people with diabetes, especially DM, are at higher risk of developing AD. AD is characterized by progressive cognitive decline and accumulation of β-amyloid (Aβ) forming senile plaques. DM is a metabolic disorder characterized by hyperglycemia in the context o...

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Prevalence of Onychomycosis in Type 2 Diabetes Mellitus

Abstract Background and Objective: Onychomycosis is a fungal nail infection causing ulcers, diabetic foot and enhance nail infection. This study was designed to evaluate the prevalence of onychomycosis in type II diabetes. Material and methods: This descriptive-analytic study was conducted on 300 diabetic patients selected randomly among those referred to Panje Azar endocrinology clinic. ...

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Pathophysiology of type 2 diabetes.

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions...

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Evaluation of Sexual Function in Men with Diabetes Mellitus Type 2- Yazd Diabetes Research Center

Objective: Sexual dysfunction is considered as an important health problems. Chronic diseases such as diabetes can have negative effect on sexual function. This study aims to determine the level of sexual dysfunction in male patients with diabetes mellitus type 2 in Yazd Diabetics Research Center. Materials and Methods: This descriptive study involved 69 male patients with type 2 diabetes mell...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2020

ISSN: 1422-0067

DOI: 10.3390/ijms21176275